Mohan S, Barohn R J, Jackson C E, Krolick K A
Department of Microbiology, University of Texas Health Science Center at San Antonio 78284.
Clin Immunol Immunopathol. 1994 Mar;70(3):266-73. doi: 10.1006/clin.1994.1039.
In the study described below, 97 myasthenia gravis (MG) patients have been evaluated for antibody reactivity against muscle myosin. With few exceptions, we could clearly observe a positive correlation between the presence of circulating serum anti-myosin antibodies and disease severity. Unlike some studies of anti-striational antibodies in MG patients, no association with thymoma was apparent. Moreover, no relationships were revealed between the severity of disease symptoms demonstrated and absolute anti-myosin antibody titers or prominent IgG subclasses. Therefore, we suggest that expression of myosin reactivity may be one useful parameter for predicting disease severity in those patients, but it is not prerequisite for induction of MG.
在如下所述的研究中，97例重症肌无力（MG）患者接受了针对肌肉肌球蛋白的抗体反应性评估。除少数例外情况，我们能够清楚地观察到循环血清抗肌球蛋白抗体的存在与疾病严重程度之间呈正相关。与一些关于MG患者抗横纹肌抗体的研究不同，未发现与胸腺瘤有明显关联。此外，所表现出的疾病症状严重程度与抗肌球蛋白抗体绝对滴度或显著的IgG亚类之间未显示出相关性。因此，我们认为肌球蛋白反应性的表达可能是预测这些患者疾病严重程度的一个有用参数，但它并非引发MG的必要条件。
