载脂蛋白AI浓度和高密度脂蛋白亚组分的多变量遗传分析：主要基因座多效性的证据。

Multivariate genetic analysis of apo AI concentration and HDL subfractions: evidence for major locus pleiotropy.

作者信息

Blangero J, Williams-Blangero S, Mahaney M C

机构信息

Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78228-0147.

出版信息

Genet Epidemiol. 1993;10(6):617-22. doi: 10.1002/gepi.1370100648.

DOI:10.1002/gepi.1370100648

PMID:8314070

Abstract

A major locus influencing apolipoprotein AI (apo AI) serum levels was detected using data from the Donner Laboratory Family Study. This locus accounts for 46% of the phenotypic variability in apo AI levels. Multivariate segregation analysis revealed that this major locus also has significant pleiotropic effects on the relative distribution of high density lipoproteins.

摘要

利用唐纳实验室家族研究的数据，检测到一个影响载脂蛋白AI（apo AI）血清水平的主要基因座。该基因座占apo AI水平表型变异的46%。多变量分离分析显示，这个主要基因座对高密度脂蛋白的相对分布也有显著的多效性作用。