Ohkawa H, Iwakawa T, Ohtomo N, Kitayama M, Miyahara A, Matsuki A
Department of Anesthesiology, University of Hirosaki School of Medicine.
Masui. 1993 Apr;42(4):557-61.
Effect of total intravenous anesthesia with droperidol, fentanyl and ketamine (DFK) on peripheral circulation was studied by examining core-peripheral temperature gradient in twenty five patients who underwent abdominal surgery. A core temperature probe was attached on the forehead and peripheral probe on the palm of the hand of the side on which the blood pressure cuff was not applied. The temperature gradient was less than three degrees centigrade in 60% of the patients and the gradient was significantly less as compared with that of isoflurane anesthesia even at 300 minutes after the start of surgical operation. This advantage would have been caused by such factors as circulatory stimulating effect of ketamine, sympathetic blocking effect by droperidol and adequate postoperative analgesia by fentanyl and norketamine, a metabolite of ketamine. The results suggest that DFK would exert a beneficial effect on peripheral circulation, particularly during prolonged surgical procedures.
通过检测25例接受腹部手术患者的中心-外周温度梯度，研究了氟哌利多、芬太尼和氯胺酮全静脉麻醉（DFK）对外周循环的影响。将中心温度探头贴在前额，外周探头贴在未绑血压袖带一侧的手掌上。60%的患者温度梯度小于3摄氏度，即使在手术开始300分钟后，该梯度也明显低于异氟烷麻醉时的梯度。这种优势可能是由氯胺酮的循环刺激作用、氟哌利多的交感神经阻滞作用以及芬太尼和氯胺酮代谢产物去甲氯胺酮充分的术后镇痛作用等因素导致的。结果表明，DFK对外周循环有有益作用，尤其是在长时间手术过程中。
