Riikonen P, Leinonen M, Jalanko H, Hovi L, Saarinen U M
Children's Hospital, University of Helsinki, Finland.
Acta Paediatr. 1993 Apr;82(4):355-9. doi: 10.1111/j.1651-2227.1993.tb12696.x.
In a prospective study, 91 episodes of fever in neutropenic children with cancer were evaluated. Fifteen episodes were septicemias, verified by a positive blood culture, 62 were fevers of unknown origin, 6 were focal infections and 8 were of other etiologies (i.e. drug fevers and viral infections). Serum antibody responses to bacteria were measured in paired sera by an enzyme immunoassay method. Bacterial infection was demonstrated serologically in 20% of documented septicemias, in 35% of fevers of unknown origin and occasionally in the other groups. Tests were available and found positive in the fever of unknown origin group for Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Moraxella (Branhamella) catarrhalis and enterobacteria. Some had multiple etiology. In conclusion, bacterial serology is a promising method of identifying bacterial etiology in fever of otherwise unknown origin in neutropenic children with cancer.
在一项前瞻性研究中，对91例患有癌症的中性粒细胞减少儿童的发热情况进行了评估。15例为败血症，血培养阳性得以证实；62例为不明原因发热；6例为局灶性感染；8例为其他病因（即药物热和病毒感染）。采用酶免疫测定法检测配对血清中对细菌的血清抗体反应。在20%已确诊的败血症、35%不明原因发热病例以及其他组中偶尔可通过血清学方法证实存在细菌感染。在不明原因发热组中，针对金黄色葡萄球菌、肺炎链球菌、流感嗜血杆菌、卡他莫拉菌（布兰汉菌属）和肠杆菌的检测结果呈阳性。部分病例存在多种病因。总之，细菌血清学是一种很有前景的方法，可用于识别患有癌症的中性粒细胞减少儿童不明原因发热的细菌病因。
