慢性髓性白血病中的残留Ph-细胞：检测及其用途
Residual Ph- cells in chronic myeloid leukemia: detection and usefulness.
作者信息
Chang J, Coutinho L H, Santos A M, Brereton M, Harrison C J, Testa N G
机构信息
Department of Experimental Hematology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.
出版信息
Stem Cells. 1993 May;11 Suppl 1:59-61. doi: 10.1002/stem.5530110612.
Bone marrow cells from patients with chronic myeloid leukemia (CML) in in vitro long-term bone marrow culture (LTBMC) show an impaired survival of Philadelphia (Ph) positive cells and, in a proportion of patients, the emergence of Philadelphia negative hemopoiesis. The standard conditions of in vitro cultures provide optimal purging effect. Selected patients can now have autologous bone marrow transplants (ABMT) with in vitro purged cells.
慢性粒细胞白血病（CML）患者的骨髓细胞在体外长期骨髓培养（LTBMC）中显示费城（Ph）阳性细胞的存活受损，并且在一部分患者中出现费城阴性造血。体外培养的标准条件可提供最佳的净化效果。现在，选定的患者可以接受经体外净化细胞的自体骨髓移植（ABMT）。
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