Matsui T
Department of Medicine, Kobe University School of Medicine.
Nihon Rinsho. 1993 Jun;51(6):1656-62.
Distinct genes encode alpha and beta PDGF receptors which differ in their abilities to be triggered by three dimeric forms of the PDGF molecule. Each receptor is able to independently couple with mitogenic signal transduction pathways, and both are capable of inducing a readily detectable chemotactic response. The vascular smooth muscle cells which express both types of PDGF receptor are mitogenic and chemotactic for PDGFs. Moreover, the alpha receptor is the preferred receptor for platelet PDGF AB as well as the PDGF-AA isoform which is ubiquitously produced in many cells forming atherosclerotic plaques including macrophages, endothelial cells and even arterial smooth muscle cells. The availability of specific PDGF isoforms and the relative expression of each receptor gene product appear to be the major determinants of the PDGF response. An understanding of the molecular mechanisms by which the expression of PDGF and their receptors on vascular smooth muscle will give greater insights as to how these gene products are involved in atherosclerosis.
不同的基因编码α和β血小板衍生生长因子（PDGF）受体，它们被PDGF分子的三种二聚体形式触发的能力有所不同。每种受体都能够独立地与促有丝分裂信号转导途径偶联，并且两者都能够诱导易于检测到的趋化反应。表达两种类型PDGF受体的血管平滑肌细胞对PDGF具有促有丝分裂和趋化作用。此外，α受体是血小板PDGF AB以及在包括巨噬细胞、内皮细胞甚至动脉平滑肌细胞在内的许多形成动脉粥样硬化斑块的细胞中普遍产生的PDGF-AA同种型的首选受体。特定PDGF同种型的可用性以及每种受体基因产物的相对表达似乎是PDGF反应的主要决定因素。了解PDGF及其受体在血管平滑肌上表达的分子机制，将更深入地了解这些基因产物如何参与动脉粥样硬化。
