Effect of multiple injections of antigen on prolonged IgE antibody production in hypersensitive mice.
作者信息
Altman R, Levine B B
出版信息
J Allergy Clin Immunol. 1977 Feb;59(2):120-7. doi: 10.1016/0091-6749(77)90213-5.
PMID:833380
Abstract
Multiple injections of ovomucoid were given to mice with ongoing prolonged IgE antibody production to that antigen. Two inbred strains and antigen doses ranging from 0.05 to 5 mug each injection, given intradermally and subcutaneously, were used. Mice treated in this manner showed a marked diminution of the Ig E antibody booster response as compared to controls. This decrease in booster response was antigen-specific. In addition, a protective effect from anaphylaxis was indicated. The mouse model continues to be a valuable tool for studies of certain IgE-mediated diseases.
摘要
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