溶血巴斯德氏菌A1中编码30 kDa膜蛋白的串联多基因分析。
Analysis of tandem, multiple genes encoding 30-kDa membrane proteins in Pasteurella haemolytica A1.
作者信息
Murphy G L, Whitworth L C
机构信息
Oklahoma State University, Department of Veterinary Pathology, Stillwater 74078.
出版信息
Gene. 1993 Jul 15;129(1):107-11. doi: 10.1016/0378-1119(93)90704-7.
A number of outer membrane proteins (OMPs), including a 30-kDa protein, may be important in eliciting immunity to Pasteurella haemolytica A1, the causative agent of bovine pneumonic pasteurellosis. To better understand the nature of the 30-kDa antigen, several genes encoding this protein were sequenced. Sequence analysis revealed that three separate genes encoding similar, yet distinct, versions of the 30-kDa protein are tandemly arranged on the P. haemolytica A1 chromosome. The genes appear to be transcribed from a single promoter. The deduced amino acid sequences of the proteins encoded by these genes are similar to a 28-kDa inner membrane lipoprotein of Escherichia coli and a 28-kDa membrane protein which may contribute to the virulence of Haemophilus influenzae type b strains.
一些外膜蛋白（OMPs），包括一种30 kDa的蛋白，可能在引发针对溶血巴斯德菌A1（牛肺巴氏杆菌病的病原体）的免疫反应中起重要作用。为了更好地了解30 kDa抗原的性质，对编码该蛋白的几个基因进行了测序。序列分析表明，三个分别编码相似但又不同版本的30 kDa蛋白的基因串联排列在溶血巴斯德菌A1染色体上。这些基因似乎从一个单一启动子转录。这些基因编码的蛋白的推导氨基酸序列与大肠杆菌的一种28 kDa内膜脂蛋白以及可能对b型流感嗜血杆菌菌株毒力有贡献的一种28 kDa膜蛋白相似。
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