Anker N, Francis D, Viskum K
Medicinsk afdeling, Roskilde Amts Sygehus.
Ugeskr Laeger. 1993 Jul 26;155(30):2354-6.
The course of disease in two women with bioptically verified lymphangioleiomyomatosis (LAM) is demonstrated. One was oestrogen- and progesterone-receptor negative, but responded promptly to hysterosalpingo-oophorectomy and has had no symptoms later. The other was receptor positive, but in spite of hysterosalpingo-oophorectomy and hormonal manipulation with tamoxifen and medroxyprogesterone, has had a complicated course of the disease with symptoms for ten years. LAM is a hormone dependent disease, but our knowledge is still incomplete. Hormonal manipulation should be tried in receptor positive as well as negative patients. Tamoxifen seems to have deleterious effects on the course of disease.
本文展示了两名经活检证实患有淋巴管平滑肌瘤病（LAM）的女性患者的病程。其中一名患者雌激素和孕激素受体均为阴性，但接受子宫输卵管卵巢切除术后迅速起效，此后未再出现症状。另一名患者受体为阳性，尽管接受了子宫输卵管卵巢切除术以及使用他莫昔芬和甲羟孕酮进行激素治疗，但其病程仍很复杂，出现症状长达十年。LAM是一种激素依赖性疾病，但我们对此的了解仍不完整。对于受体阳性和阴性的患者都应尝试进行激素治疗。他莫昔芬似乎对疾病进程有不良影响。
