Bäumler A, Koebnik R, Stojiljkovic I, Heesemann J, Braun V, Hantke K
Lehrstuhl für Mikrobiologie II, Universität Tübingen, Germany.
Zentralbl Bakteriol. 1993 Apr;278(2-3):416-24. doi: 10.1016/s0934-8840(11)80858-3.
Iron assimilation systems have been shown to be important for virulence in Yersinia enterocolitica. In principle, iron transport in Y. enterocolitica is similarly organized as in Escherichia coli although some differences exist in the siderophores used. A TonB function was identified which in a tonB mutant was complemented by the E. coli tonB gene. Three outer membrane receptors for siderophores were cloned and sequenced: FoxA for ferrioxamine B and E, FcuA for ferrichrome and HemR for heme uptake. In addition, two receptors were identified by mutants: CccA for catechol cephalosporins and FyuA for yersiniabactin, the siderophore produced by virulent yersiniae. In addition, the FyuA protein is assumed to be the pesticin receptor.
铁同化系统已被证明对小肠结肠炎耶尔森菌的毒力很重要。原则上，小肠结肠炎耶尔森菌中的铁转运组织方式与大肠杆菌相似，尽管在使用的铁载体方面存在一些差异。已鉴定出一种TonB功能，在tonB突变体中，该功能可由大肠杆菌的tonB基因互补。克隆并测序了三种铁载体的外膜受体：用于铁胺B和E的FoxA、用于高铁色素的FcuA以及用于血红素摄取的HemR。此外，通过突变体鉴定出了两种受体：用于儿茶酚头孢菌素的CccA和用于耶尔森菌素（由有毒力的耶尔森菌产生的铁载体）的FyuA。此外，FyuA蛋白被认为是杀有害素受体。
