Baserga R, Porcu P, Sell C
Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Cancer Surv. 1993;16:201-13.
Recent advances in the field of cell cycle progression have extended our knowledge of the mechanism(s) of cellular proliferation and have placed it on a solid molecular basis. This survey highlights some of these findings, selecting the most intriguing in the hope of providing new insights on cell cycle controls. We have considered two large groups of factors involved in cell cycle control: extracellular (environmental signals, ie growth factors, and their cellular receptors) and intracellular (oncogenes and anti-oncogenes), indicating which, to us, may be the most promising areas of investigation. These include the events occurring after the IGF1 receptor is activated by its ligand, the role of anti-oncogenes in preventing the activation of growth factor receptors, the mechanism(s) by which some proto-oncogenes may short circuit the cell cycle and the use of peptide analogues and the antisense strategy to study and to regulate cellular proliferation.
细胞周期进程领域的最新进展拓展了我们对细胞增殖机制的认识，并将其建立在坚实的分子基础之上。本综述着重介绍了其中一些发现，挑选出最引人入胜的部分，以期为细胞周期调控提供新的见解。我们考虑了参与细胞周期调控的两大类因素：细胞外因素（环境信号，即生长因子及其细胞受体）和细胞内因素（癌基因和抗癌基因），指出了在我们看来最具研究前景的领域。这些领域包括胰岛素样生长因子1（IGF1）受体被其配体激活后发生的事件、抗癌基因在阻止生长因子受体激活中的作用、某些原癌基因可能使细胞周期短路的机制，以及使用肽类似物和反义策略来研究和调节细胞增殖。
