Christiansen J, Lauritzen K, Moesgaard J, Holst J J
Scand J Gastroenterol. 1977;12(1):33-6.
The effect of endogenously released pancreatic glucagon on pentagastrin-stimulated lower esophageal sphincter pressure (LES-P) was studied in 10 healthy subjects. Glucagon was released by continuous intravenous infusion of 1-arginine in a dose of 0.6 g/kg-h, which resulted in plasma concentrations of pancreatic glucagon comparable to those seen after a protein meal. Infusion of arginine resulted in a significant inhibition of pentagastrin (0.5 mug/kg-h) stimulated LES-P. Five of the subjects furthermore had a study of the effect of exogenous glucagon in a dose of 1.6 mjg/kg-h on pentagastrin-stimulated LES-P. This dose of glucagon also reduced LES-P, but in spite of higher plasma glucagon concentrations, to a lesser degree than arginine.
在10名健康受试者中研究了内源性释放的胰高血糖素对五肽胃泌素刺激的食管下括约肌压力（LES-P）的影响。通过以0.6 g/kg-h的剂量持续静脉输注1-精氨酸来释放胰高血糖素，这导致血浆中胰高血糖素的浓度与进食蛋白质餐后的浓度相当。输注精氨酸导致五肽胃泌素（0.5 μg/kg-h）刺激的LES-P显著降低。此外，5名受试者还研究了1.6 μg/kg-h剂量的外源性胰高血糖素对五肽胃泌素刺激的LES-P的影响。该剂量的胰高血糖素也降低了LES-P，但尽管血浆胰高血糖素浓度较高，其降低程度小于精氨酸。
