Rowley D A, Stach R M
Department of Pathology, University of Chicago, Illinois 60637.
J Exp Med. 1993 Sep 1;178(3):835-40. doi: 10.1084/jem.178.3.835.
A first or dominant immunization with one antigen markedly inhibited specific cytolytic T lymphocyte (CTL) responses to a second unrelated alloantigen without suppressing antibody responses to other antigens. Suppression was induced rapidly, became systemic, and could be transferred passively with only serum. Suppression did not result from elimination of cells capable of responding to the second antigen. The mechanisms responsible for this "priority of the first response" may be the same that help protect the fetus during pregnancy, promote renal allograft survival after multiple blood transfusions, and prevent effective CTL-mediated immunity to variants of tumor cells or infectious agents that arise during tumor progression or chronic infections.
首次或用一种抗原进行主要免疫时，会显著抑制针对第二种不相关同种异体抗原的特异性细胞毒性T淋巴细胞（CTL）反应，而不会抑制对其他抗原的抗体反应。抑制作用迅速诱导产生，成为全身性的，并且仅通过血清就能被动转移。抑制并非由于能够对第二种抗原作出反应的细胞被清除所致。导致这种“首次反应优先”的机制可能与孕期保护胎儿、多次输血后促进肾移植存活以及防止对肿瘤进展或慢性感染期间出现的肿瘤细胞或传染因子变体产生有效的CTL介导免疫的机制相同。
