Hikasa Y, Kubota M, Takase K, Kakuta T, Ogasawara S
Department of Veterinary Surgery, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori, Japan.
Vet Surg. 1993 Jul-Aug;22(4):311-7. doi: 10.1111/j.1532-950x.1993.tb00406.x.
The effects of thiopental, ketamine, diazepam, xylazine, and nitrous oxide, and the combinations of thiopental-nitrous oxide and ketamine-nitrous oxide, on both enflurane-induced electroencephalographic (EEG) spike activity and convulsive behavior were measured quantitatively in atropinized cats receiving enflurane with controlled ventilation. Pretreatments with thiopental, ketamine, and diazepam reduced both EEG spike frequency and amplitude at 2.5% to 4.5% inspired enflurane but did not abolish spike activity. Nitrous oxide (66% of inspired gas) did not significantly alter spike frequency or amplitude during 2.5% to 4.5% inspired enflurane, but the combination of thiopental-nitrous oxide or ketamine-nitrous oxide reduced EEG spike activity during 2.5% inspired enflurane. Enflurane-induced convulsive score was markedly suppressed by thiopental and ketamine and was significantly reduced by diazepam, xylazine and nitrous oxide. The combinations of thiopental-nitrous oxide and ketamine-nitrous oxide greatly reduced behavioral-convulsive responses induced by 2.5% to 4.5% inspired enflurane.
在接受恩氟烷并控制通气的阿托品化猫中，定量测定了硫喷妥钠、氯胺酮、地西泮、赛拉嗪和氧化亚氮，以及硫喷妥钠 - 氧化亚氮和氯胺酮 - 氧化亚氮组合对恩氟烷诱导的脑电图（EEG）尖峰活动和惊厥行为的影响。硫喷妥钠、氯胺酮和地西泮预处理可降低吸入恩氟烷浓度为2.5%至4.5%时的EEG尖峰频率和幅度，但并未消除尖峰活动。氧化亚氮（吸入气体的66%）在吸入恩氟烷浓度为2.5%至4.5%时，并未显著改变尖峰频率或幅度，但硫喷妥钠 - 氧化亚氮或氯胺酮 - 氧化亚氮组合在吸入恩氟烷浓度为2.5%时可降低EEG尖峰活动。硫喷妥钠和氯胺酮可显著抑制恩氟烷诱导的惊厥评分，地西泮、赛拉嗪和氧化亚氮可显著降低该评分。硫喷妥钠 - 氧化亚氮和氯胺酮 - 氧化亚氮组合可极大地降低吸入恩氟烷浓度为2.5%至4.5%时诱发的行为惊厥反应。
