体外培养的添加或不添加雌二醇的MCF-7细胞对化疗和内分泌治疗的敏感性差异。
Different chemo- and endocrino-sensitivity of MCF-7 cells with or without estradiol supplement in vitro.
作者信息
Tanino H, Kubota T, Saikawa Y, Kuo T H, Takeuchi T, Kase S, Furukawa T, Kitajima M, Sakurai T, Naito Y
机构信息
Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
出版信息
Anticancer Res. 1993 Jul-Aug;13(4):1219-21.
The sensitivity of MCF-7 cells to tamoxifen (TAM) and mitomycin C (MMC) was assessed in rapidly and slowly growing cells with or without estradiol supplementation, respectively. The growth of MCF-7 was inhibited by MMC in a concentration-dependent manner with or without estradiol (E2) supplementation. Preincubation with MMC suppressed subsequent E2 stimulated growth of MCF-7. TAM inhibited the growth of MCF-7 supplemented with E2 and preincubation with TAM prevented subsequent E2 stimulated growth of MCF-7. However, TAM did not inhibit the growth of MCF-7 cells in E2 free medium. These results suggested that MMC may be more effective than TAM on breast cancer cells in the dormant or slow-growth phase.
分别在添加或不添加雌二醇的快速生长和缓慢生长的细胞中评估MCF-7细胞对他莫昔芬（TAM）和丝裂霉素C（MMC）的敏感性。无论是否添加雌二醇（E2），MMC均以浓度依赖性方式抑制MCF-7的生长。用MMC预孵育可抑制随后E2刺激的MCF-7生长。TAM抑制添加E2的MCF-7生长，用TAM预孵育可阻止随后E2刺激的MCF-7生长。然而，TAM在无E2的培养基中不抑制MCF-7细胞的生长。这些结果表明，MMC对处于休眠或缓慢生长阶段的乳腺癌细胞可能比TAM更有效。
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