c-MYC通过核心启动子元件对启动子活性的抑制作用。
c-MYC repression of promoter activity through core promoter elements.
作者信息
Lucas J M, Wilkie N M, Lang J C
机构信息
Department of Hematology and Oncology, Ohio State University Hospital, Columbus.
出版信息
Biochem Biophys Res Commun. 1993 Aug 16;194(3):1446-52. doi: 10.1006/bbrc.1993.1987.
PMID:8352803
Abstract
c-MYC was found to repress expression of the c-myc promoter in a transient assay system. Deletion constructs showed the cis-acting element(s) were common to both the P1 and P2 promoters. Further analysis involving replacement of the P2 TATA box and initiator elements with the SV40 late promoter initiator localized the cis-acting elements to the core promoter.
摘要
在瞬时检测系统中发现c-MYC可抑制c-myc启动子的表达。缺失构建体显示顺式作用元件对于P1和P2启动子是共同的。进一步的分析包括用SV40晚期启动子起始子替换P2 TATA盒和起始子元件，将顺式作用元件定位到核心启动子。
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