表皮生长因子对围产期大鼠鸟氨酸脱羧酶活性及DNA合成的影响。
Effects of epidermal growth factor on ornithine decarboxylase activity and DNA synthesis in rats during the perinatal period.
作者信息
Yamamoto D, Hiramatsu Y, Eguchi K, Kudo T
机构信息
Department of Obstetrics and Gynecology, Okayama University Medical School, Japan.
出版信息
Biol Neonate. 1993;63(5):303-9. doi: 10.1159/000243946.
The effects of epidermal growth factor (EGF) on ornithine decarboxylase (ODC) activity and DNA synthesis were studied during the perinatal period in rats. EGF administration to neonatal rats increased ODC activity and DNA synthesis in neonatal rat liver, but not in brain. EGF administration to maternal rats increased ODC activity in maternal rat liver, but not in rat placenta and fetal rat liver. These data suggest that EGF has mitogenic effects on neonatal and maternal rat liver and play some important roles in fetal and neonatal growth.
在围产期大鼠中研究了表皮生长因子（EGF）对鸟氨酸脱羧酶（ODC）活性和DNA合成的影响。给新生大鼠注射EGF可增加新生大鼠肝脏中的ODC活性和DNA合成，但对大脑无此作用。给母鼠注射EGF可增加母鼠肝脏中的ODC活性，但对大鼠胎盘和胎鼠肝脏无此作用。这些数据表明，EGF对新生和母鼠肝脏具有促有丝分裂作用，并在胎儿和新生儿生长中发挥一些重要作用。
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