Ljunghall S, Hedstrand H, Hellsing K, Wibell L
Acta Med Scand. 1977 Jan;201(1-2):23-30.
Serum valuse for calcium, phosphate and albumin have been determined in a population study of 2322 49-50-year-old men participating in a health examination survey. Calcium and albumin were significantly correlated (r = 0.34) but adjustment for albumin only caused minor effects on the distribution of calcium. No inverse relationship was found between calcium and phosphate. Seasonal variations over the three years of the health survey could not be established for either calcium or phosphate, whereas there was a slight tendency for albumin to decline during summer. The prevalence of hyperparathyroidism (HPT) in this population of men up to the age of 50 was 0.3% and among those with recurrent renal stones 5.3%. All subjects with verified HPT had a history of recurrent renal stones. One man on thiazide treatment had a slight elevation of calcium which returned to normal after cessation of the drug. No other case of hypercalcemia besides those caused by HPT was found. Mean values and frequency distributions for calcium, phosphate and albumin were almost identical in renal stone formers and matched controls. Hence it seems likely that other factors than those which markedly affect serum levels of calcium and phosphate are of major importance in common renal stone formation.
在一项针对2322名49 - 50岁男性的健康检查调查的人群研究中，测定了血清钙、磷和白蛋白的值。钙和白蛋白显著相关（r = 0.34），但仅对白蛋白进行校正对钙的分布影响较小。未发现钙和磷之间存在负相关关系。在健康调查的三年中，未确定钙或磷有季节性变化，而白蛋白在夏季有轻微下降趋势。在该50岁以下男性人群中，甲状旁腺功能亢进症（HPT）的患病率为0.3%，在复发性肾结石患者中为5.3%。所有确诊为HPT的受试者都有复发性肾结石病史。一名接受噻嗪类药物治疗的男性钙水平略有升高，停药后恢复正常。除HPT引起的高钙血症外，未发现其他高钙血症病例。肾结石患者和匹配对照组的钙、磷和白蛋白的平均值及频率分布几乎相同。因此，在常见肾结石形成中，除了那些显著影响血清钙和磷水平的因素外，其他因素似乎更为重要。
