体重减轻对患有阻塞性睡眠呼吸暂停综合征的肥胖男性肺功能的影响。

Effects of weight loss on pulmonary function in obese men with obstructive sleep apnoea syndrome.

作者信息

Largerstrand L, Rössner S

机构信息

Department of Clinical Physiology, Huddinge Hospital, Sweden.

出版信息

J Intern Med. 1993 Sep;234(3):245-7. doi: 10.1111/j.1365-2796.1993.tb00739.x.

DOI:10.1111/j.1365-2796.1993.tb00739.x

PMID:8354974

Abstract

The effects of long-term behaviour modification of obesity on pulmonary function was studied in eight men with obstructive sleep apnoea syndrome (initial mean body mass index [BMI] 41.8 kg m-2) before and after a mean weight loss of 20 +/- 7 (SD) kg. Mean arterial PCO2 fell from 6.3 +/- 1.2 to 5.5 +/- 0.6 kPa (P < 0.05) and concomitant significant improvements were found in vital capacity, total lung capacity, functional residual capacity and forced expired volume (FEV 1.0). The study suggests that weight loss per se, rather than the method of choice to achieve weight loss, results in clinically significant improvement of pulmonary function in obese men.

摘要

在8名患有阻塞性睡眠呼吸暂停综合征的男性（初始平均体重指数[BMI]为41.8kg/m²）中，研究了长期肥胖行为改变对肺功能的影响，这些男性平均体重减轻了20±7（标准差）kg。平均动脉二氧化碳分压从6.3±1.2降至5.5±0.6kPa（P<0.05），同时肺活量、肺总量、功能残气量和用力呼气量（FEV1.0）也有显著改善。该研究表明，体重减轻本身，而非实现体重减轻的选择方法，会导致肥胖男性的肺功能在临床上得到显著改善。