Hovi I, Taavitsainen M, Lantto T, Vorne M, Paul R, Remes K
Clinic of Radiology, Helsinki University Hospital, Finland.
J Nucl Med. 1993 Sep;34(9):1428-34.
To evaluate the usefulness of 99mTc-HMPAO-labeled leukocytes and 99mTc-labeled polyclonal human immunoglobulin G (Technescan HIG) in the diagnosis of focal purulent disease, 31 comparative scintigraphies were done in 30 patients with known or strongly suspected focal infection. Focal purulent disease was the final diagnosis in 19 patients. Technetium-99m-labeled leukocytes showed 16 true-positive, no false-positive, 11 true-negative and 3 false-negative findings. The corresponding figures for 99mTc-labeled HIG were 11, 2, 9 and 8. The sensitivity and specificity of imaging with labeled leukocytes were 84% and 100%, respectively, and with labeled HIG, 58% and 82%, respectively. The overall accuracy of the leukocyte scan was significantly better than that of the HIG scan (90% versus 67%, p < 0.001). Thus, if focal infection is suspected, scintigraphy with 99mTc-labeled leukocytes is the preferable method. No cases exhibited a better imaging result with 99mTc-HIG scintigraphy than with 99mTc-labeled leukocytes.
为评估99mTc-HMPAO标记的白细胞和99mTc标记的多克隆人免疫球蛋白G（Technescan HIG）在局灶性化脓性疾病诊断中的效用，对30例已知或高度怀疑局灶性感染的患者进行了31次对比闪烁扫描。19例患者最终诊断为局灶性化脓性疾病。99mTc标记的白细胞显示16例假阳性、无假阴性、11例假阴性和3例假阴性结果。99mTc标记的HIG的相应数字分别为11、2、9和8。标记白细胞成像的敏感性和特异性分别为84%和100%，标记HIG成像的敏感性和特异性分别为58%和82%。白细胞扫描的总体准确性明显优于HIG扫描（90%对67%，p<0.001）。因此，如果怀疑局灶性感染，99mTc标记白细胞闪烁扫描是更好的方法。没有病例显示99mTc-HIG闪烁扫描的成像结果优于99mTc标记白细胞闪烁扫描。
