Wakayama I, Kihira T, Yoshida S, Garruto R M
Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
Dementia. 1993 Mar-Apr;4(2):75-80. doi: 10.1159/000107300.
Using three different silver impregnation methods and antisera against microtubule-associated protein-tau (MAP-tau) and amyloid beta/A4 protein, we demonstrated abundant neurofibrillary tangles (NFTs), rare senile plaques, absence of amyloid angiopathy and rare MAP-tau- and silver-positive neuropil threads in the hippocampus of patients with amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) on Guam and in the Kii Peninsula of Japan. In contrast, abundant neuropil threads, NFTs, senile plaques with associated dystrophic neurites and amyloid angiopathy were confirmed in Alzheimer disease patients. These observations indicate that there may be important factor(s) responsible for the difference in the deposition and distribution of amyloid beta/A4 protein and MAP-tau between Pacific ALS and PD and Alzheimer disease.
我们使用三种不同的银浸染方法以及针对微管相关蛋白tau（MAP-tau）和β淀粉样蛋白/A4蛋白的抗血清，在关岛肌萎缩侧索硬化症（ALS）和帕金森痴呆症（PD）患者以及日本纪伊半岛患者的海马体中，证实存在大量神经原纤维缠结（NFTs）、罕见的老年斑、无淀粉样血管病以及罕见的MAP-tau和银阳性神经毡丝。相比之下，在阿尔茨海默病患者中证实存在大量神经毡丝、NFTs、伴有营养不良性神经突的老年斑以及淀粉样血管病。这些观察结果表明，可能存在重要因素导致太平洋地区ALS和PD与阿尔茨海默病之间β淀粉样蛋白/A4蛋白和MAP-tau的沉积及分布存在差异。
