近红外光谱技术（NIRS）：一种用于研究成年人类大脑功能激活过程中血流动力学变化的新工具。

Near infrared spectroscopy (NIRS): a new tool to study hemodynamic changes during activation of brain function in human adults.

作者信息

Villringer A, Planck J, Hock C, Schleinkofer L, Dirnagl U

机构信息

Department of Neurology, University of Munich, FRG.

出版信息

Neurosci Lett. 1993 May 14;154(1-2):101-4. doi: 10.1016/0304-3940(93)90181-j.

DOI:10.1016/0304-3940(93)90181-j

PMID:8361619

Abstract

In healthy human adults, cerebral concentrations of oxygenated hemoglobin ([HbO2]) and deoxygenated hemoglobin ([HbR]) were assessed during brain activation using near infrared spectroscopy (NIRS). Measurements were made either in the frontal cortex (n = 10) during performance of cognitive tasks or in the occipital cortex (n = 6) during visual stimulation (flash-light exposure, picture observation). The typical findings during brain activation were an increase in [HbO2] and a decrease in [HbR]. We demonstrate that these findings are not due to alterations in skin blood flow. NIRS is a simple bedside technique for the assessment of hemodynamic alterations accompanying brain activation.

摘要

在健康成年人体内，使用近红外光谱（NIRS）在大脑激活过程中评估了氧合血红蛋白（[HbO2]）和脱氧血红蛋白（[HbR]）的脑浓度。测量是在认知任务执行期间于额叶皮质（n = 10）进行的，或者是在视觉刺激（闪光灯照射、图片观察）期间于枕叶皮质（n = 6）进行的。大脑激活期间的典型发现是[HbO2]增加而[HbR]减少。我们证明这些发现并非由于皮肤血流的改变所致。NIRS是一种用于评估伴随大脑激活的血流动力学改变的简单床边技术。