Goldman B D, Oh S K, Davis B E, Kadin M E, Poiesz B J, Koh H K
Department of Dermatology, Boston University School of Medicine, Mass.
Arch Dermatol. 1993 Sep;129(9):1166-70.
Cutaneous T-cell lymphoma (CTCL) comprises a spectrum of presentations, including erythroderma, pruritus, lymphadenopathy, and circulating atypical lymphocytes. Photopheresis is an extracorporeal treatment in which white blood cell concentrates are subjected to UV irradiation when the serum methoxypsoralen level is above 50 ng/mL. Of patients with CTCL, those with erythroderma have been most responsive to this therapy. In some conditions, including certain malignant hematologic neoplasms, serum soluble interleukin 2 receptor levels (SIL2R) correlate with disease activity. We sought to determine whether serum SIL2R levels correlated with disease activity in six erythrodermic patients with CTCL treated primarily with photopheresis. We measured SIL2R levels in five patients with stage III or greater erythrodermic CTCL and one with stage IIa CTCL. We compared SIL2R values with clinical course, skin scores, CD4/CD8 ratios, peripheral white blood cell counts, and Sézary cell counts, using Pearson correlation coefficients.
The SIL2R levels correlated with clinical course and skin scores, even when controlled for other factors noted above.
Data preliminarily suggest that serum SIL2R levels may be useful indicators of disease activity in erythrodermic CTCL patients treated with photopheresis.
皮肤T细胞淋巴瘤（CTCL）有多种表现形式，包括红皮病、瘙痒、淋巴结病和循环中的非典型淋巴细胞。光分离置换疗法是一种体外治疗方法，当血清甲氧沙林水平高于50 ng/mL时，白细胞浓缩物会接受紫外线照射。在CTCL患者中，红皮病患者对这种疗法反应最为明显。在某些情况下，包括某些恶性血液肿瘤，血清可溶性白细胞介素2受体水平（SIL2R）与疾病活动相关。我们试图确定在主要接受光分离置换疗法治疗的6例红皮病型CTCL患者中，血清SIL2R水平是否与疾病活动相关。我们测量了5例III期或更严重红皮病型CTCL患者和1例IIa期CTCL患者的SIL2R水平。我们使用Pearson相关系数将SIL2R值与临床病程、皮肤评分、CD4/CD8比值、外周血白细胞计数和Sezary细胞计数进行比较。
即使在控制了上述其他因素后，SIL2R水平仍与临床病程和皮肤评分相关。
数据初步表明，血清SIL2R水平可能是接受光分离置换疗法治疗的红皮病型CTCL患者疾病活动的有用指标。
