Mountain R E, Glasby M A, Sharp J F, Murray J A
Department of Otolaryngology, Royal Infirmary, Edinburgh, UK.
Clin Otolaryngol Allied Sci. 1993 Jun;18(3):171-7. doi: 10.1111/j.1365-2273.1993.tb00823.x.
Freeze-thawed co-axially aligned skeletal muscle autografts provide a new concept in peripheral nerve repair, and are being investigated in the repair of mixed motor/sensory nerves. These grafts provide an orientated matrix of large basement membrane tubes through which regenerating axons can migrate and reinnervate the distal nerve. Using the buccal branch of the rat facial nerve as a model, we compared five freeze-thawed muscle autografts with five interposed nerve autografts. Some 300 days after grafting, the morphology of the distal nerve was evaluated. When the two groups were assessed morphometrically, it was found that nerve grafts showed a small but significant improvement over muscle grafts in respect of indices of the fibre maturation.
冻融同轴排列的骨骼肌自体移植为周围神经修复提供了一个新概念，目前正在对其在混合运动/感觉神经修复中的应用进行研究。这些移植物提供了一个由大的基底膜管组成的定向基质，再生轴突可以通过该基质迁移并重新支配远端神经。以大鼠面神经颊支为模型，我们将5个冻融肌肉自体移植物与5个插入神经自体移植物进行了比较。移植约300天后，对远端神经的形态进行了评估。当对两组进行形态计量学评估时，发现神经移植物在纤维成熟指数方面比肌肉移植物有微小但显著的改善。
