[非甾体类抗风湿药在下消化道的副作用]
[Side effects of non-steroidal antirheumatic agents in the lower intestinal tract].
作者信息
Bielecki J W, Filippini L
机构信息
Gastroenterologische Abteilung, Kantonsspital Luzern.
出版信息
Schweiz Med Wochenschr. 1993 Jul 24;123(29):1419-28.
Side effects of non-steroid anti-inflammatory drugs (NSAIDs) on the lower intestinal tract are reviewed. NSAID use may exacerbate or reactivate quiescent inflammatory bowel disease. There are distinct types of NSAID-induced enterocolitis: ulcerative colitis, Crohn's disease, and necrotizing enterocolitis in premature infants. It is also suggested that NSAIDs may play an etiological role in collagenous colitis. Furthermore, NSAIDs may induce ulcerations, perforations and strictures in the small as well as large bowel. Occult and severe blood loss from lower intestinal tract under treatment with NSAIDs should be kept in mind.
本文综述了非甾体抗炎药（NSAIDs）对下肠道的副作用。使用NSAIDs可能会加重或重新激活静止期的炎症性肠病。NSAIDs引起的小肠结肠炎有不同类型：溃疡性结肠炎、克罗恩病以及早产儿坏死性小肠结肠炎。也有观点认为NSAIDs可能在胶原性结肠炎的病因学中起作用。此外，NSAIDs可导致小肠和大肠出现溃疡、穿孔及狭窄。应牢记在NSAIDs治疗过程中下肠道隐匿性和严重失血的情况。
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