由Gs刺激的腺苷酸环化酶进行信号识别与整合。

Signal recognition and integration by Gs-stimulated adenylyl cyclases.

作者信息

Pieroni J P, Jacobowitz O, Chen J, Iyengar R

机构信息

Mount Sinai School of Medicine, Department of Pharmacology, New York, NY 10029-6574.

出版信息

Curr Opin Neurobiol. 1993 Jun;3(3):345-51. doi: 10.1016/0959-4388(93)90127-k.

DOI:10.1016/0959-4388(93)90127-k

PMID:8369627

Abstract

Six Gs-stimulated adenylyl cyclases have been cloned. Two additional forms have been identified as partial cDNAs. These adenylyl cyclases have distinct functional properties and are differentially regulated by protein kinases. The adenylyl cyclases have distinct patterns of distribution in peripheral tissues and various brain regions. The unique functional characteristics of the members of this effector family may allow each cell type and/or brain region to customize the signal-recognition and integrative properties of its cAMP-generation system by varying the ratios of the various adenylyl cyclases.

摘要

六种受G刺激的腺苷酸环化酶已被克隆。另外两种形式已被鉴定为部分互补DNA。这些腺苷酸环化酶具有不同的功能特性，并受到蛋白激酶的差异调节。腺苷酸环化酶在外周组织和不同脑区具有不同的分布模式。这个效应器家族成员的独特功能特性可能使每种细胞类型和/或脑区通过改变各种腺苷酸环化酶的比例来定制其环磷酸腺苷生成系统的信号识别和整合特性。