Walsh W R, Guzelsu N
Department of Orthopaedics, Brown University School of Medicine, Rhode Island Hospital, Providence 02903.
Biomed Mater Eng. 1993 Summer;3(2):75-84.
Bone tissue is a composite material composed of an inorganic stiff mineral phase embedded in a compliant organic matrix. Similar to other composites, the mechanical properties of bone depend upon the properties, volume fraction, and orientation of its constituents as well as the bonding interactions. Interfacial bonding between the mineral and organic constituents are based, in part, on electrostatic interactions between negatively charged organic domains and positively charged mineral surface. Phosphate and fluoride ions can alter mineral-organic interfacial causing a permutation in the mechanical properties. Partial debonding between the mineral and organic constituents of bone may play an important role in the mechanical properties of aged and diseased bone. The present study examines the effects of phosphate and fluoride ion treatment on the compression properties of cortical bone and the reversibility of the effect.
骨组织是一种复合材料，由嵌入柔软有机基质中的无机硬矿物质相组成。与其他复合材料类似，骨的力学性能取决于其成分的性质、体积分数和取向以及键合相互作用。矿物质和有机成分之间的界面结合部分基于带负电荷的有机域与带正电荷的矿物质表面之间的静电相互作用。磷酸根离子和氟离子可改变矿物质-有机界面，从而导致力学性能发生变化。骨的矿物质和有机成分之间的部分脱粘可能在老化和患病骨骼的力学性能中起重要作用。本研究考察了磷酸根离子和氟离子处理对皮质骨压缩性能的影响以及该影响的可逆性。
