Schouman-Claeys E, Henry-Feugeas M C, Roset F, Larroche J C, Hassine D, Sadik J C, Frija G, Gabilan J C
Department of Radiology, Raymond Poincaré Hospital, Garches, France.
Radiology. 1993 Oct;189(1):59-64. doi: 10.1148/radiology.189.1.8372220.
To correlate magnetic resonance (MR) imaging and pathologic findings in premature infants with periventricular leukomalacia (PVL).
Eight premature infants with PVL who died after 3-7 weeks of life were studied with in vivo T1-weighted MR imaging, and imaging patterns were compared with hypoxic-ischemic injuries at pathologic analysis.
Cavities were seen as zones of absent or weak signal intensity. Translucent sparsely cellular zones appeared as areas of intermediate intensity, and cellular reactions were seen as limited linear or punctate zones of increased intensity, usually less intense than the cortex. MR imaging provided reliable depiction of these lesions, with adequate estimation of their volume and topography. However, the extent of periventricular cellular lesions was underestimated. In one case, blood seen as hyperintense or isointense zones masked portions of cystic lesions, and in three cases small thalamic lesions were overlooked.
With the above limitations, T1-weighted MR imaging offers precise evaluation of PVL.
将患有脑室周围白质软化症（PVL）的早产儿的磁共振（MR）成像与病理结果进行关联。
对8例出生后3 - 7周死亡的患有PVL的早产儿进行了活体T1加权MR成像研究，并将成像模式与病理分析中的缺氧缺血性损伤进行比较。
空洞表现为无信号或低信号强度区域。半透明的细胞稀疏区表现为中等强度区域，细胞反应表现为强度增加的有限线性或点状区域，通常比皮质强度低。MR成像能够可靠地描绘这些病变，并能对其体积和形态进行充分估计。然而，脑室周围细胞病变的范围被低估了。在1例中，表现为高信号或等信号区域的血液掩盖了部分囊性病变，在3例中，小的丘脑病变被忽略。
尽管存在上述局限性，T1加权MR成像仍能对PVL进行精确评估。
