（羟基苯氧基）甲基杂芳盐的氨基甲酸酯类作为乙酰胆碱酯酶抑制剂和针对有机磷化合物的保护剂。
Carbamates of (hydroxyphenoxy)methyl heteroaromatic salts as acetylcholinesterase inhibitors and protective agents against organophosphorus compounds.
作者信息
Sundberg R J, Dalvie D, Cordero J, Sabat M, Musallam H A
机构信息
Department of Chemistry, University of Virginia, Charlottesville 22901.
出版信息
Chem Res Toxicol. 1993 Jul-Aug;6(4):500-5. doi: 10.1021/tx00034a017.
PMID:8374048
Abstract
A series of N,N-dimethylcarbamates of 2-[(2'-, 3'-, and 4'-hydroxyphenoxy)methyl] heteroaromatic salts has been prepared. Pyridine, imidazole, quinoline, benzimidazole, and imidazo-[1,2-alpha]pyridine derivatives were included. Most of the compounds are inhibitors of electric eel acetylcholinesterase and also show prophylactic activity toward a 2LD50 dose of soman in mice.
摘要
已制备了一系列2-[(2'-, 3'-, 和4'-羟基苯氧基)甲基]杂芳盐的N,N-二甲基氨基甲酸酯。其中包括吡啶、咪唑、喹啉、苯并咪唑和咪唑并[1,2-α]吡啶衍生物。大多数化合物是电鳗乙酰胆碱酯酶的抑制剂，并且对小鼠2LD50剂量的梭曼也显示出预防活性。
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