Pietraszek M H, Choudhury N A, Baba S, Sakaguchi S, Hachiya T, Urano T, Takada Y, Takada A
Department of Surgery and Physiology, Hamamatsu University, School of Medicine, Shizuoka-ken, Japan.
Int Angiol. 1993 Mar;12(1):9-12.
Whole blood and plasma levels of serotonin (5-hydroxy-tryptamine, 5-HT) as well as its uptake and spontaneous release from blood platelets were studied in 20 patients suffering from thromboangiitis obliterans (TAO, Buerger's disease) and 20 healthy subjects matched in pairs for age. Results of patients suffering from thromboangiitis obliterans differed in several ways from those of controls. Whole blood 5-HT content was significantly lower in the group of patients compared to that of the control group. It was established that patients with Buerger's disease have significantly greater plasma concentrations of free serotonin. In Buerger's disease patients, maximal platelet serotonin uptake velocity (Vmax) was significantly decreased. It was associated with the enhanced spontaneous release of 5-HT from blood platelets. We conclude that impaired platelet serotonin uptake and increased local concentration of serotonin in the vicinity of platelets in Buerger's disease may lead to platelet activation via 5-HT2 receptors, and it could be involved in the pathogenesis of thromboembolic complications.
对20例血栓闭塞性脉管炎（TAO，伯格氏病）患者和20名年龄匹配的健康受试者的全血和血浆中血清素（5-羟色胺，5-HT）水平及其从血小板的摄取和自发释放进行了研究。血栓闭塞性脉管炎患者的结果在几个方面与对照组不同。与对照组相比，患者组的全血5-HT含量显著降低。已确定伯格氏病患者的游离血清素血浆浓度显著更高。在伯格氏病患者中，血小板血清素最大摄取速度（Vmax）显著降低。这与血小板5-HT的自发释放增强有关。我们得出结论，伯格氏病中血小板血清素摄取受损以及血小板附近血清素局部浓度增加可能通过5-HT2受体导致血小板活化，并且可能参与血栓栓塞并发症的发病机制。
