果糖-1,6-二磷酸酶与肌醇单磷酸酶之间的结构相似性。
Structural similarities between fructose-1,6-bisphosphatase and inositol monophosphatase.
作者信息
Zhang Y, Liang J Y, Lipscomb W N
机构信息
Gibbs Chemical Laboratory, Harvard University, Cambridge, MA 02138.
出版信息
Biochem Biophys Res Commun. 1993 Feb 15;190(3):1080-3. doi: 10.1006/bbrc.1993.1159.
Fructose-1,6-bisphosphatase and inositol monophosphatase are found to share a similar secondary structure topology even though their sequences have very limited homology. Both enzymes have a layered alpha beta alpha beta alpha type structure and similar tertiary structures. All but one of the metal binding residues are conserved between these two enzymes and homologous proteins. The exception is Glu-280 in fructose-1,6-bisphosphatase to Asp-220 in inositol monophosphatase.
尽管果糖-1,6-二磷酸酶和肌醇单磷酸酶的序列同源性非常有限，但发现它们具有相似的二级结构拓扑。这两种酶都具有αββαβ型分层结构和相似的三级结构。这两种酶和同源蛋白之间，除了一个金属结合残基外，其他所有残基都是保守的。例外的是，果糖-1,6-二磷酸酶中的Glu-280对应于肌醇单磷酸酶中的Asp-220。
Zotero 插件