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Nucleotide sequence of the Chinese hamster Na+/H+ exchanger NHE1.

作者信息

Counillon L, Pouysségur J

机构信息

Centre de Biochimie-CNRS, Université de Nice-Sophia Antipolis, France.

出版信息

Biochim Biophys Acta. 1993 Mar 20;1172(3):343-5. doi: 10.1016/0167-4781(93)90228-6.

DOI:10.1016/0167-4781(93)90228-6
PMID:8383540
Abstract

We have cloned and sequenced the cDNA coding for the Chinese hamster Na+/H+ antiporter expressed in the CCL39 fibroblast cell line. This cDNA contains an open reading frame encoding a protein of 822 amino acids which is homologous to the human NHE1 isoform. Sequence comparison studies show that the first cytoplasmic loop of the transporter is completely different between the two species indicating that the conservation of this domain is not required for the function of the antiporter.

摘要

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