大鼠锥体外系运动功能中多巴胺 - 5-羟色胺相互作用的脊髓上调节

Supraspinal mediation of dopamine-serotonin interactions in extrapyramidal motor functions in the rat.

作者信息

Wadenberg M L, Hillegaart V, Berge O G

机构信息

Department of Psychology, University of Stockholm, Sweden.

出版信息

Neuroreport. 1993 Jan;4(1):59-61. doi: 10.1097/00001756-199301000-00015.

DOI:10.1097/00001756-199301000-00015

PMID:8384019

Abstract

The effects of intracerebroventricularly (i.c.v.) or intrathecally (i.t.) administrated 8-OH-DPAT on catalepsy, induced by the specific DA D2 antagonist raclopride (16 mg kg-1 s.c.), were studied in rats. It was found that 8-OH-DPAT (0.5 or 2.0 micrograms kg-1) injected by the i.c.v. route produced a statistically significant of raclopride-induced catalepsy at both doses. In contrast, 8-OH-DPAT (0.2 or 2.0 micrograms kg-1) given by the i.t. route had no statistically significant effect on the raclopride-induced catalepsy. These results suggest that the antagonistic effect of 8-OH-DPAT on catalepsy, induced by DA blocking agents, is primarily mediated at the supraspinal level.

摘要

研究了向大鼠脑室内（i.c.v.）或鞘内（i.t.）注射8-羟基二丙胺基四氢萘（8-OH-DPAT）对由特异性多巴胺D2拮抗剂雷氯必利（16 mg/kg，皮下注射）诱导的僵住症的影响。结果发现，通过脑室内途径注射的8-OH-DPAT（0.5或2.0微克/千克）在两种剂量下均对雷氯必利诱导的僵住症产生了统计学上显著的影响。相比之下，通过鞘内途径给予的8-OH-DPAT（0.2或2.0微克/千克）对雷氯必利诱导的僵住症没有统计学上的显著影响。这些结果表明，8-OH-DPAT对多巴胺阻断剂诱导的僵住症的拮抗作用主要是在脊髓上水平介导的。