Wilkinson E J, Smith L J
Department of Pathology, University of Florida College of Medicine, Gainesville.
J Fla Med Assoc. 1993 Feb;80(2):106-11.
Almost 70 human papillomavirus (HPV) types have been identified. An estimated one-third are anogenital associated. Their presence in the genital tract is associated with cancer, and certain particular types have a high correlation with cervical intraepithelial neoplasia (CIN) and carcinoma. Although a spectrum of histopathologic features within the epithelium characterize changes caused by HPV infection, only DNA analysis accurately detects and determines the type of infection. The variety of molecular methods for detection of HPV DNA primarily reveal whether or not a lesion is in fact associated with HPV infection. For minor grade cervical squamous lesions or equivocal Pap smear results, HPV detection and typing can help identify patients at increased risk for cervical carcinoma. Cervical colposcopy and biopsy are indicated for definitive diagnosis.
已鉴定出近70种人乳头瘤病毒（HPV）类型。据估计，其中三分之一与肛门生殖器相关。它们在生殖道中的存在与癌症有关，某些特定类型与宫颈上皮内瘤变（CIN）和癌高度相关。尽管上皮内的一系列组织病理学特征可表征HPV感染引起的变化，但只有DNA分析才能准确检测并确定感染类型。检测HPV DNA的多种分子方法主要用于揭示病变是否实际上与HPV感染有关。对于轻度宫颈鳞状病变或巴氏涂片结果不明确的情况，HPV检测和分型有助于识别宫颈癌风险增加的患者。明确诊断需要进行宫颈阴道镜检查和活检。
