迈向针对16型人乳头瘤病毒生殖器感染的疫苗

Towards vaccines against human papillomavirus type-16 genital infections.

作者信息

Cason J, Khan S A, Best J M

机构信息

Richard DimbleBy Laboratory of Cancer Virology, United Medical and Dental Schools, Rayne Institute, London, UK.

出版信息

Vaccine. 1993;11(6):603-11. doi: 10.1016/0264-410x(93)90302-e.

DOI:10.1016/0264-410x(93)90302-e

PMID:8391738

Abstract

Human papillomavirus type-16 (HPV-16) is strongly associated with cervical carcinoma and cervical intraepithelial neoplasia. It may soon be possible to develop prophylactic vaccines designed to induce neutralizing antibodies to HPV-16 virions in genital secretions and therapeutic vaccines to induce cytotoxic T-cell responses against HPV-16 early proteins in cervical intraepithelial neoplasia and cervical cancers. Although significant advances have been achieved, problems remain before such vaccines can be used routinely.

摘要

16型人乳头瘤病毒（HPV - 16）与宫颈癌及宫颈上皮内瘤变密切相关。不久后，有可能研发出预防性疫苗，用于诱导机体产生针对生殖器分泌物中HPV - 16病毒颗粒的中和抗体，以及治疗性疫苗，以诱导机体产生针对宫颈上皮内瘤变和宫颈癌中HPV - 16早期蛋白的细胞毒性T细胞反应。尽管已经取得了重大进展，但在这类疫苗能够常规使用之前，问题依然存在。