腹腔注射白三烯B4（LTB4）和ω-胍基己酸甲磺酸盐（GCA）可提高耐甲氧西林金黄色葡萄球菌（MRSA）攻击小鼠的存活率。

Intraperitoneal administration of leukotriene B4 (LTB4) and omega-guanidino caproic acid methane sulfonate (GCA) increased the survival of mice challenged with methicillin-resistant Staphylococcus aureus (MRSA).

作者信息

Yamamoto S, Adjei A A, Kise M

机构信息

Department of Nutrition, University of the Ryukyus Okinawa, Japan.

出版信息

Prostaglandins. 1993 Jun;45(6):527-34. doi: 10.1016/0090-6980(93)90016-z.

DOI:10.1016/0090-6980(93)90016-z

PMID:8393205

Abstract

Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) very often complicate management of immunocompromised patients. We studied the effect of leukotriene B4 (LTB4) and epsilon-guanidino caproic acid methane sulfonate (GCA), on MRSA infection. Mice fed a 20% casein diet were intraperitoneally administered LTB4, GCA, or saline (control) daily for 30 days. On the 10th day of this treatment, mice were challenged with MRSA. The survival rate in the control group (20%) was significantly lower than the rates in the GCA (60%) and LTB4 (50%) groups, respectively (p < 0.05). There was a significant reduction of MRSA in the spleen and kidney of the survived mice in GCA group as against mice in the LTB4 and saline groups, indicating a better recovery in GCA group than the other groups. The results suggest that intraperitoneal administration of GCA and LTB4 may play a role in host defense mechanism during MRSA infections.

摘要

耐甲氧西林金黄色葡萄球菌（MRSA）引起的感染常常使免疫功能低下患者的治疗复杂化。我们研究了白三烯B4（LTB4）和ε-胍基己酸甲磺酸盐（GCA）对MRSA感染的影响。给喂食20%酪蛋白饮食的小鼠每天腹腔注射LTB4、GCA或生理盐水（对照组），持续30天。在该治疗的第10天，用MRSA对小鼠进行攻击。对照组的存活率（20%）分别显著低于GCA组（60%）和LTB4组（50%）（p<0.05）。与LTB4组和生理盐水组的小鼠相比，GCA组存活小鼠的脾脏和肾脏中的MRSA显著减少，表明GCA组比其他组恢复得更好。结果表明，腹腔注射GCA和LTB4可能在MRSA感染期间的宿主防御机制中发挥作用。