斜视眼阵挛-肌阵挛中的促肾上腺皮质激素抗体

Antibodies to ACTH in opsoclonus-myoclonus.

作者信息

Pranzatelli M R, Kao P C, Tate E D, Chaves E, Chez M, Dobyns W B, Kang H, Rothner D A

机构信息

Department of Neurology, George Washington University, Washington, D.C.

出版信息

Neuropediatrics. 1993 Jun;24(3):131-3. doi: 10.1055/s-2008-1071529.

DOI:10.1055/s-2008-1071529

PMID:8395029

Abstract

Antibodies to ACTH1-24 detected by radioimmunoassay were present in the serum of a child with opsoclonus-myoclonus for at least 24 weeks after discontinuation of chronic ACTH treatment. The antibody-bound ACTH did not interfere with cortisol secretion. Six other children with opsoclonus-myoclonus and 16 control sera, including patients with chronically elevated endogenous ACTH, did not exhibit autoantibodies to ACTH. Antibodies to ACTH should be sought in patients who develop tolerance to ACTH treatment. The indirect but not direct ACTH assay method is sensitive to the presence of ACTH antibodies.

摘要

通过放射免疫测定法检测到，一名患眼阵挛-肌阵挛的儿童在停止长期促肾上腺皮质激素（ACTH）治疗后至少24周，其血清中存在抗促肾上腺皮质激素1-24抗体。抗体结合的促肾上腺皮质激素并不干扰皮质醇分泌。另外六名患眼阵挛-肌阵挛的儿童以及16份对照血清（包括内源性促肾上腺皮质激素长期升高的患者）均未表现出抗促肾上腺皮质激素自身抗体。对于对促肾上腺皮质激素治疗产生耐受性的患者，应检测其抗促肾上腺皮质激素抗体。间接而非直接的促肾上腺皮质激素测定方法对促肾上腺皮质激素抗体的存在敏感。