Porter R H, Roberts P J
Department of Physiology and Pharmacology, University of Southampton, UK.
Neurosci Lett. 1993 May 14;154(1-2):78-80. doi: 10.1016/0304-3940(93)90175-k.
The sulphur-containing acidic amino acids (SAAs) display neuroexcitatory actions similar to those of L-glutamate and are widely regarded as bona fide transmitter candidates. In this study, L-cysteine sulphinic acid, L-cysteic acid, DL-homocysteic acid and L-homocysteine sulphinic acid were investigated for their ability to stimulate phosphatidylinositol hydrolysis in rat pup cerebrocortical slices and compared with L-glutamate and the selective agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD). Each of the SAAs possessed agonist activity at metabotropic glutamate receptors (mGluRs) and, although they exhibited lower efficacy than L-glutamate, they were more potent (EC50s of 401-487 microM compared with 791 microM for L-glutamate). These data are consistent with the possibility that SAAs may have a physiological role as endogenous activators of metabotropic (and presumably ionotropic) excitatory amino acid receptors.
含硫酸性氨基酸(SAAs)表现出与L-谷氨酸类似的神经兴奋作用,被广泛认为是真正的递质候选物。在本研究中,研究了L-半胱亚磺酸、L-半胱磺酸、DL-高半胱氨酸和L-高半胱亚磺酸刺激大鼠幼崽大脑皮质切片中磷脂酰肌醇水解的能力,并与L-谷氨酸和选择性激动剂(1S,3R)-1-氨基环戊烷-1,3-二羧酸((1S,3R)-ACPD)进行比较。每种SAA在代谢型谷氨酸受体(mGluRs)上都具有激动剂活性,尽管它们的效力低于L-谷氨酸,但它们更有效(EC50为401-487 microM,而L-谷氨酸为791 microM)。这些数据与SAAs可能作为代谢型(可能还有离子型)兴奋性氨基酸受体的内源性激活剂发挥生理作用的可能性一致。