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含硫兴奋性氨基酸对新生大鼠大脑皮层中代谢型谷氨酸受体的激活作用。

Glutamate metabotropic receptor activation in neonatal rat cerebral cortex by sulphur-containing excitatory amino acids.

作者信息

Porter R H, Roberts P J

机构信息

Department of Physiology and Pharmacology, University of Southampton, UK.

出版信息

Neurosci Lett. 1993 May 14;154(1-2):78-80. doi: 10.1016/0304-3940(93)90175-k.

Abstract

The sulphur-containing acidic amino acids (SAAs) display neuroexcitatory actions similar to those of L-glutamate and are widely regarded as bona fide transmitter candidates. In this study, L-cysteine sulphinic acid, L-cysteic acid, DL-homocysteic acid and L-homocysteine sulphinic acid were investigated for their ability to stimulate phosphatidylinositol hydrolysis in rat pup cerebrocortical slices and compared with L-glutamate and the selective agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD). Each of the SAAs possessed agonist activity at metabotropic glutamate receptors (mGluRs) and, although they exhibited lower efficacy than L-glutamate, they were more potent (EC50s of 401-487 microM compared with 791 microM for L-glutamate). These data are consistent with the possibility that SAAs may have a physiological role as endogenous activators of metabotropic (and presumably ionotropic) excitatory amino acid receptors.

摘要

含硫酸性氨基酸(SAAs)表现出与L-谷氨酸类似的神经兴奋作用,被广泛认为是真正的递质候选物。在本研究中,研究了L-半胱亚磺酸、L-半胱磺酸、DL-高半胱氨酸和L-高半胱亚磺酸刺激大鼠幼崽大脑皮质切片中磷脂酰肌醇水解的能力,并与L-谷氨酸和选择性激动剂(1S,3R)-1-氨基环戊烷-1,3-二羧酸((1S,3R)-ACPD)进行比较。每种SAA在代谢型谷氨酸受体(mGluRs)上都具有激动剂活性,尽管它们的效力低于L-谷氨酸,但它们更有效(EC50为401-487 microM,而L-谷氨酸为791 microM)。这些数据与SAAs可能作为代谢型(可能还有离子型)兴奋性氨基酸受体的内源性激活剂发挥生理作用的可能性一致。

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