钠摄入对肾小球及血管紧张素升压反应的分离效应。

Dissociated effect of sodium intake on glomerular and pressor responses to angiotensin.

作者信息

Hornych H, Richet G

出版信息

Kidney Int. 1977 Jan;11(1):28-34. doi: 10.1038/ki.1977.4.

DOI:10.1038/ki.1977.4

Abstract

The influence of chronic and acute changes in sodium intake on pressor and glomerular capillary responses to angiotensin was studied. Scanning electron microscopy was used to observe the capillary changes in the superficial glomeruli. The results showed that both responses was sodium-dependent but in opposite directions. Low sodium intake diminished the pressor effect but enhanced the glomerular capillary response to administered angiotensin. On the contrary, a high sodium diet or a short perfusion of 0.9% NaC1 considerably diminished the sensitivity of the glomerular capillaries to angiotensin, whereas the systemic hypertensive effect was enhanced. Our results demonstrate that the systemic circulation and the capillaries of the superficial glomeruli react independently to angiotensin. This suggests that the superficial glomerular receptors differ from the systemic ones.

摘要

研究了钠摄入量的慢性和急性变化对血管升压和肾小球毛细血管对血管紧张素反应的影响。采用扫描电子显微镜观察浅表肾小球的毛细血管变化。结果表明，两种反应均依赖于钠，但方向相反。低钠摄入减弱了血管升压作用，但增强了肾小球毛细血管对给予的血管紧张素的反应。相反，高钠饮食或短期灌注0.9%氯化钠显著降低了肾小球毛细血管对血管紧张素的敏感性，而全身高血压作用增强。我们的结果表明，体循环和浅表肾小球的毛细血管对血管紧张素的反应是独立的。这表明浅表肾小球受体与全身受体不同。