Paspaliaris V, Mai X, Leaver D D
Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia.
Life Sci. 1993;53(15):1227-34. doi: 10.1016/0024-3205(93)90541-a.
Foscarnet inhibited noradrenaline and calcium-mediated contractions of the isolated perfused tail artery of the rat. When the noradrenaline contractile response was split into two components, where the first was due to the release of calcium from intracellular stores and the second to the influx of calcium from the extracellular fluid, foscarnet (30 microM) inhibited only the first component of the response. Foscarnet did not inhibit the calcium influx component of the noradrenaline contraction, nor did it affect the inhibition of this component by the L-type calcium channel antagonists verapamil and nicardipine. These results indicate that foscarnet inhibits vascular smooth muscle contraction by inhibiting calcium release from intracellular stores.
膦甲酸钠抑制大鼠离体灌注尾动脉中去甲肾上腺素和钙介导的收缩。当去甲肾上腺素收缩反应分为两个成分时，其中第一个成分是由于细胞内钙库释放钙，第二个成分是由于细胞外液钙内流，膦甲酸钠（30微摩尔）仅抑制反应的第一个成分。膦甲酸钠不抑制去甲肾上腺素收缩的钙内流成分，也不影响L型钙通道拮抗剂维拉帕米和尼卡地平对该成分的抑制作用。这些结果表明，膦甲酸钠通过抑制细胞内钙库释放钙来抑制血管平滑肌收缩。
