Lettieri L, Rodis J F, Vintzileos A M, Feeney L, Ciarleglio L, Craffey A
Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington.
Obstet Gynecol. 1993 Jan;81(1):57-60.
To test the hypothesis that small ears have diagnostic value in detecting second-trimester aneuploid fetuses by ultrasound.
We prospectively studied 452 patients with singleton pregnancies undergoing ultrasound examination for genetic amniocentesis at 14-25 weeks and an additional 30 singleton pregnancies at 20-25 weeks with a negative anomaly screen. Standard fetal biometry measurements were obtained, including ear length (from helix to end of lobe).
Of these patients, 424 (88%) had ear measurements obtained, and a nomogram for ear length by gestational age was compiled. The relationship between ear length and gestational age was linear across the second trimester (r = 0.84, P < .001). Fourteen fetuses had aneuploidy by amniocentesis, of whom ten had ear lengths at or below the tenth percentile. The sensitivity was 71% and the specificity 92% (377 of 410). Positive and negative predictive values were 23% (ten of 43) and 99% (377 of 381), respectively.
Fetal ear length may be useful in identifying aneuploid fetuses sonographically during the second trimester.
检验关于小耳朵在超声检测孕中期非整倍体胎儿方面具有诊断价值这一假设。
我们前瞻性地研究了452名单胎妊娠患者，她们在14至25周时接受超声检查以进行遗传羊膜腔穿刺术，另外还研究了30名单胎妊娠患者，她们在20至25周时进行了异常筛查且结果为阴性。获取了标准的胎儿生物测量数据，包括耳长（从耳轮至耳垂末端）。
在这些患者中，424名（88%）有耳长测量数据，并编制了按孕周划分的耳长列线图。孕中期耳长与孕周之间的关系呈线性（r = 0.84，P < .001）。通过羊膜腔穿刺术检测出14名胎儿为非整倍体，其中10名胎儿的耳长处于或低于第十百分位数。敏感性为71%，特异性为92%（410名中的377名）。阳性预测值和阴性预测值分别为23%（43名中的10名）和99%（381名中的377名）。
胎儿耳长在孕中期超声检查识别非整倍体胎儿方面可能有用。
