Aran J M, de Sauvage R C
Acta Otolaryngol. 1977 Jan-Feb;83(1-2):153-59. doi: 10.3109/00016487709128826.
During etacrynic acid intoxication in the guinea pig, patterns of click-evoked compound electrocochleographic responses are similar to those observed in Menière and retro-cochlear human pathologies. Using high frequency tone bursts, SP, CM and AP were studied after intracardiac injection of etacrynic acid. The evolution of SP precedes that of CM and AP. Its change in polarity could be related to that reported for EP by Bosher et al. (1973). While during the recovery period SP overshoots (after 90 min), CM and AP increase more slowly (up to about 7 days) and in most cases AP amplitudes do not exceed 70-80% of their original value (25 days). N1, when present, keeps its classical pattern durint the entire evolution, whatever its amplitude and latency variations are. The early positive peak or negative shift observed in click-evoked human pathological electrocochleography can therefore be identified as SP. Thus this response is the indication of the presence of hair cells and of the impairment of the nerve fibre stimulation or response.
在豚鼠依他尼酸中毒期间，短声诱发的复合电耳蜗图反应模式与梅尼埃病和蜗后性人类病变中观察到的相似。使用高频短音，在心内注射依他尼酸后研究了总和电位（SP）、耳蜗微音电位（CM）和动作电位（AP）。SP的变化先于CM和AP。其极性变化可能与博舍等人（1973年）报道的耳内电位（EP）的变化有关。在恢复期间，SP会出现过冲（90分钟后），而CM和AP增加得更慢（长达约7天），并且在大多数情况下，AP振幅不会超过其原始值的70-80%（25天）。当存在N1时，无论其振幅和潜伏期如何变化，在整个演变过程中都保持其经典模式。因此，在人类病理性电耳蜗图中观察到的早期正峰或负向移位可被确定为SP。因此，这种反应表明存在毛细胞以及神经纤维刺激或反应受损。
