Shimada M, Segawa M, Higurashi M, Akamatsu H
Department of Maternal and Child Health, School of Health Sciences, Faculty of Medicine, University of Tokyo, Japan.
Pediatr Res. 1993 Feb;33(2):159-63. doi: 10.1203/00006450-199302000-00014.
The purpose of this study was to investigate the effect of constant light in a neonatal care unit on the development of the sleep-and-wakefulness rhythm in preterm infants. Two groups of infants (57 preterm infants without other complications and 58 healthy term infants) were prospectively studied over infancy by a day-by-day plot method, by which sleep-and-wakefulness states were recorded at home for more than 14 d to compare developmental courses of the sleep-and-wakefulness rhythm between the two groups at corrected and postnatal ages. In the two groups, there were no significant differences in distribution of emergence of periodicity of sleep states and wakeful states, total sleep time, nocturnal sleep time, diurnal sleep time, longest sustained sleep period, and longest sustained wakeful period at the same corrected ages. Moreover, the SD of the time of onset of the longest sustained sleep period of each subject diminished with increase in postconceptional weeks. The results suggest that the development of the sleep-and-wakefulness rhythm in preterm infants is not necessarily retarded if they are discharged from the neonatal care unit under constant light before an infant's innate biologic clock is mature enough to respond to an environmental cycle; rather it depends on their corrected ages.
本研究旨在探讨新生儿重症监护病房持续光照对早产儿睡眠-觉醒节律发育的影响。采用逐日记录法，对两组婴儿（57例无其他并发症的早产儿和58例健康足月儿）进行了前瞻性研究，在家中记录睡眠-觉醒状态超过14天，以比较两组婴儿在矫正年龄和出生后年龄时睡眠-觉醒节律的发育过程。在两组中，相同矫正年龄时，睡眠状态和觉醒状态周期性出现的分布、总睡眠时间、夜间睡眠时间、白天睡眠时间、最长持续睡眠时间和最长持续觉醒时间均无显著差异。此外，随着孕龄周数的增加，每个受试者最长持续睡眠时间开始时间的标准差减小。结果表明，如果早产儿在其先天生物钟成熟到足以对环境周期做出反应之前在持续光照下从新生儿重症监护病房出院，其睡眠-觉醒节律的发育不一定会受到阻碍；相反，这取决于他们的矫正年龄。
