Brophy P D, Borowski T B, Kokkinidis L
Department of Psychology, University of Saskatchewan, Saskatoon, Canada.
Pharmacol Biochem Behav. 1993 Feb;44(2):425-8. doi: 10.1016/0091-3057(93)90485-c.
The relationship between amygdaloid brain-stimulation reward and the evolution of seizure activity was evaluated in this study. Current levels that maintained optimal intracranial self-stimulation (ICSS) rates were found to be lower than the minimal current intensity required to elicit an afterdischarge (AD) from the central nucleus of the amygdala. After the ICSS session, AD thresholds (ADTs) were reduced to the same levels of current used to support ICSS. Assessment of seizure stage development during ICSS testing revealed that the emergence of early-stage epileptiform events following repeated amygdaloid stimulation suppressed ICSS performance. While administration of the antimuscarinic scopolamine did not prevent the stimulation-elicited reduction in AD thresholds, it was observed to inhibit seizure progression and increase ICSS rates. These results are consistent with the excitatory function of acetylcholine in epileptogenesis and were related to the possibility that different mechanisms underlie the rewarding and seizure-inducing properties of amygdaloid stimulation.
本研究评估了杏仁核脑刺激奖赏与癫痫活动演变之间的关系。发现维持最佳颅内自我刺激（ICSS）率的电流水平低于从杏仁核中央核引发后放电（AD）所需的最小电流强度。在ICSS实验之后，AD阈值（ADTs）降低到用于支持ICSS的相同电流水平。ICSS测试期间癫痫发作阶段发展的评估显示，反复杏仁核刺激后早期癫痫样事件的出现抑制了ICSS表现。虽然给予抗胆碱能药物东莨菪碱不能预防刺激引起的AD阈值降低，但观察到它能抑制癫痫发作进展并提高ICSS率。这些结果与乙酰胆碱在癫痫发生中的兴奋功能一致，并且与杏仁核刺激的奖赏和诱发癫痫特性背后存在不同机制的可能性有关。
