雌性大鼠肝脏葡萄糖-6-磷酸脱氢酶水平的调节

Regulation of liver glucose-6-P dehydrogenase levels in female rats.

Holten D, Carlos J R, Reichert L K, Nakayama R

Department of Biochemistry, University of California, Riverside 92521.

Comp Biochem Physiol B. 1993 Jan;104(1):115-8. doi: 10.1016/0305-0491(93)90346-7.

Abstract

Gender differences in the dietary regulation of rat liver glucose-6-P dehydrogenase activity, synthesis and mRNA levels were examined. 2. As expected, in normal rats fed a standard chow diet, females have higher G6PD activity than males because they have more G6PD mRNA and therefore a higher rate of G6PD synthesis. 3. In contrast, the decreased dietary induction in female rats is due to a more rapid rate of G6PD degradation rather than a decrease in G6PD mRNA or synthesis.

摘要

研究了大鼠肝脏葡萄糖-6-磷酸脱氢酶活性、合成及mRNA水平在饮食调节方面的性别差异。2. 正如预期的那样，在喂食标准饲料的正常大鼠中，雌性大鼠的葡萄糖-6-磷酸脱氢酶活性高于雄性，因为它们有更多的葡萄糖-6-磷酸脱氢酶mRNA，因此葡萄糖-6-磷酸脱氢酶的合成速率更高。3. 相比之下，雌性大鼠饮食诱导的降低是由于葡萄糖-6-磷酸脱氢酶降解速率更快，而不是葡萄糖-6-磷酸脱氢酶mRNA或合成减少。