Kaufmann N A, Guggenheim K
Int J Vitam Nutr Res. 1977;47(1):40-5.
Nutriture of thiamine, riboflavin and folacin was assessed by two tests: thiamine (109 subjects) by the TPP effect of erythrocyte transketolase activity and urinary excretion of thiamine (mug/g creatinine); riboflavin (81 subjects) by the activation coefficient of erythrocyte glutathione reductase and excretion of riboflavin in urine (mug/g creatinine); and folacin (91 subjects) by estimation of folacin in red blood cells and in serum (ng/ml). The following correlation coefficients (r) were obtained: transketolase activity vs thiamine excretion: -0.33; glutathione reductase vs riboflavin excretion: -33; and red blood cell folacin vs serum folacin: 0.77. When "deficient" and "low" values were defined as "not acceptable" and compared with "acceptable" values, sensitivity of thiamine excretion was 54%, of riboflavin excretion 33% and of serum folacin level 90%. The respective value of specificity were 75%, 83% and 37%. Sensitivity of thiamine excretion and of serum folacin level, respectively, increased when stricter criteria of insufficiency were applied and assessment of "deficiency" of these vitamins rather than of "non-acceptability" was attempted.
通过两项测试评估硫胺素、核黄素和叶酸的营养状况：对109名受试者通过红细胞转酮醇酶活性的TPP效应和硫胺素的尿排泄量（微克/克肌酐）来评估硫胺素；对81名受试者通过红细胞谷胱甘肽还原酶的激活系数和尿中核黄素的排泄量（微克/克肌酐）来评估核黄素；对91名受试者通过测定红细胞和血清中的叶酸（纳克/毫升）来评估叶酸。得到了以下相关系数（r）：转酮醇酶活性与硫胺素排泄量：-0.33；谷胱甘肽还原酶与核黄素排泄量：-33；红细胞叶酸与血清叶酸：0.77。当将“缺乏”和“低”值定义为“不可接受”并与“可接受”值进行比较时，硫胺素排泄的敏感性为54%，核黄素排泄的敏感性为33%，血清叶酸水平的敏感性为90%。各自的特异性值分别为75%、83%和37%。当采用更严格的不足标准并尝试评估这些维生素的“缺乏”而非“不可接受性”时，硫胺素排泄和血清叶酸水平的敏感性分别增加。
