Jansen B H, Zouridakis G, Brandt M E
Department of Electrical Engineering, University of Houston, TX 77204-4793.
Biol Cybern. 1993;68(3):275-83. doi: 10.1007/BF00224863.
Evidence is presented that a neurophysiologically-inspired mathematical model, originally developed for the generation of spontaneous EEG (electroencephalogram) activity, can produce VEP (visual evoked potential)-like waveforms when pulse-like signals serve as input. It was found that the simulated VEP activity was mainly due to intracortical excitatory connections rather than direct thalamic input. Also, the model-generated VEPs exhibited similar relationships between prestimulus EEG characteristics and subsequent VEP morphology, as seen in human data. Specifically, the large correlation between the N1 amplitude and the prestimulus alpha phase angle, and the insensitivity of P2 to the latter feature, as observed in actual VEPs to low intensity flashes, was also found in the model-generated data. These findings provide support for the hypothesis that the spontaneous EEG and the VEP are generated by some of the same neural structures and that the VEP is due to distributed activity, rather than dipolar sources.
有证据表明，一个最初为生成自发脑电图（EEG）活动而开发的受神经生理学启发的数学模型，当脉冲状信号作为输入时，可以产生类似视觉诱发电位（VEP）的波形。研究发现，模拟的VEP活动主要是由于皮质内兴奋性连接，而不是丘脑的直接输入。此外，模型生成的VEP在刺激前EEG特征与随后的VEP形态之间表现出类似的关系，这与人类数据中所见一致。具体而言，在模型生成的数据中也发现了，如在实际VEP对低强度闪光的反应中观察到的，N1振幅与刺激前α相角之间的高度相关性，以及P2对后一特征的不敏感性。这些发现为以下假设提供了支持：自发EEG和VEP是由一些相同的神经结构产生的，并且VEP是由于分布式活动，而不是偶极源。
