Emmi L, Bramati M, De Cristofaro M T, Mascalchi M, Dal Pozzo G, Marconi G P, Massai G, Passaleva A
Istituto di Allergologia e Immunologia Clinica, University of Florence, Italy.
Clin Exp Rheumatol. 1993 Jan-Feb;11(1):13-20.
Twenty-two SLE patients were examined with Magnetic Resonance Imaging (MRI) and Single Photon Emission Computed Tomography (SPECT). Multifocal areas of cerebral blood flow (CBF) defects were found in 81.8% of the patients. These alterations were present in patients with severe neurological disorders, in those with neuropsychiatric symptoms only, and also in asymptomatic cases. Anticardiolipin antibodies (aCL) were detected in all patients, but no correlation was found between serum aCL positivity and neurological involvement. The high incidence of cerebral blood flow disorders found in asymptomatic patients, and their poor correlation with the MRI alterations suggest a primary defect of CBF in these patients.
对22例系统性红斑狼疮（SLE）患者进行了磁共振成像（MRI）和单光子发射计算机断层扫描（SPECT）检查。81.8%的患者发现有多灶性脑血流（CBF）缺损区域。这些改变存在于患有严重神经疾病的患者、仅患有神经精神症状的患者以及无症状病例中。所有患者均检测到抗心磷脂抗体（aCL），但血清aCL阳性与神经受累之间未发现相关性。无症状患者中脑血流紊乱的高发生率及其与MRI改变的低相关性表明这些患者存在CBF的原发性缺陷。
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