Coast J R, Krause K M
Respiratory Physiology Unit, Texas A&M University, College Station 77843.
Med Sci Sports Exerc. 1993 Mar;25(3):335-40.
This study examined the relationship between work of breathing and estimated blood flow to and oxygen consumption by the respiratory muscles. Five subjects performed inspiratory loaded breathing and voluntary hyperpnea while ventilatory work, cardiac output, and oxygen consumption were measured. Blood flow to and oxygen consumption by the respiratory muscles were estimated by subtracting the resting from the working values of cardiac output the oxygen consumption, respectively. Loaded breathing increased cardiac output, but there was no significant correlation with work of breathing, while oxygen consumption was significantly correlated with work of breathing. During hyperpnea both cardiac output and oxygen consumption were correlated with work of breathing. Our results indicate that blood flow and oxygen consumption are increased in a regular pattern with increases in work of breathing. These results may be significant in estimating the demand of the respiratory muscles in disease and exercise.
本研究探讨了呼吸功与呼吸肌估计血流量及耗氧量之间的关系。五名受试者进行了吸气负荷呼吸和自主过度通气，同时测量了通气功、心输出量和耗氧量。通过分别从心输出量和耗氧量的工作值中减去静息值来估计呼吸肌的血流量和耗氧量。负荷呼吸增加了心输出量，但与呼吸功无显著相关性，而耗氧量与呼吸功显著相关。在过度通气期间，心输出量和耗氧量均与呼吸功相关。我们的结果表明，随着呼吸功的增加，血流量和耗氧量呈规律增加。这些结果对于估计疾病和运动中呼吸肌的需求可能具有重要意义。
