Beinlich C J, Morgan H E
Sigfried and Janet Weis Center for Research, Geisinger Clinic, Danville, PA 17822.
Mol Cell Biochem. 1993 Feb 17;119(1-2):3-9. doi: 10.1007/BF00926846.
The pig heart grows at a maximal rate in the first 2-3 days of life due to a volume overload imposed on the heart at birth. Rates of ribosome formation and protein synthesis cannot be further accelerated during in vitro perfusion with agents that increase cyclic AMP, that bind to alpha 1-adrenergic receptors or that bind to angiotensin II receptors. Growth of the heart in vivo can be restrained by treatment with an angiotensin-converting enzyme inhibitor, enalapril maleate, or an angiotensin receptor antagonist, DuP 753. In the enalapril-treated heart, norepinephrine plus propranolol, but not angiotensin II, accelerated ribosome formation. Rapid growth of the left ventricle of pig heart during the first 10 days of life is due largely to eccentric hypertrophy.
由于出生时心脏承受容量负荷，猪心脏在出生后的头2 - 3天以最大速率生长。在用增加环磷酸腺苷（cAMP）的药物、与α1 - 肾上腺素能受体结合的药物或与血管紧张素II受体结合的药物进行体外灌注期间，核糖体形成速率和蛋白质合成速率无法进一步加快。体内心脏的生长可通过用血管紧张素转换酶抑制剂马来酸依那普利或血管紧张素受体拮抗剂DuP 753治疗来抑制。在依那普利治疗的心脏中，去甲肾上腺素加普萘洛尔可加速核糖体形成，但血管紧张素II则不能。猪心脏左心室在出生后的头10天内快速生长主要归因于离心性肥大。
